ProCope--protein complex prediction and evaluation
نویسندگان
چکیده
منابع مشابه
Un–complicating protein complex prediction
Identification of protein complexes from proteomic experiments is crucial to understand not only their function but also the principles of cellular organization. Advances in experimental techniques have enabled the construction of large–scale protein–protein interaction networks, and computational methods have been developed to analyze high–throughput data. In most cases several parameters are ...
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Protein complexes are fundamental for understanding principles of cellular organizations. Accurate and fast protein complex prediction from the PPI networks of increasing sizes can serve as a guide for biological experiments to discover novel protein complexes. However, protein complex prediction from PPI networks is a hard problem, especially in situations where the PPI network is noisy. We kn...
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MOTIVATION Understanding principles of cellular organization and function can be enhanced if we detect known and predict still undiscovered protein complexes within the cell's protein-protein interaction (PPI) network. Such predictions may be used as an inexpensive tool to direct biological experiments. The increasing amount of available PPI data necessitates an accurate and scalable approach t...
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Identification of protein complexes is of great importance in the understanding of cellular organization and functions. Traditional computational protein complex prediction methods mainly rely on the topology of protein-protein interaction (PPI) networks but seldom take biological information of proteins (such as Gene Ontology (GO)) into consideration. Meanwhile, the environment relevant analys...
متن کاملProtein complex prediction based on simultaneous protein interaction network
MOTIVATION The increase in the amount of available protein-protein interaction (PPI) data enables us to develop computational methods for protein complex predictions. A protein complex is a group of proteins that interact with each other at the same time and place. The protein complex generally corresponds to a cluster in PPI network (PPIN). However, clusters correspond not only to protein comp...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2008
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/btn376